Microencapsulated multicellular tumor spheroids:preparation and use as a novel in vitro model for drug screening
نویسندگان
چکیده
منابع مشابه
Multicellular tumor spheroids in microcapsules as a novel 3D in vitro model in tumor biology
Background Advantages of microencapsulation as a 3D growth system are chemically and spatially defined 3D network of extracellular matrix components, cell-to-cell and cell-tomatrix interactions governing differentiation, proliferation and cell function in vivo. The study is aimed at i) optimization of techniques for preparing microcapsules; ii) generation of multicellular tumor spheroids (MTS) ...
متن کاملI-5: Multicellular Human Testicular Organoid: A Novel 3D In Vitro Germ Cell and Testicular Toxicity Model
Background Background: Mammalian spermatogenesis is regulated through paracrine and endocrine activity, specific cell signaling, and local control mechanisms. These highly specific signaling interactions are effectively absent upon placing testicular cells into two-dimensional primary culture. The specific changes that occur between key cell types and involved spermatogenesis signaling pathways...
متن کاملA Novel Mucilage from Ficus glomerata Fruits for Transdermal Patches: Taking Indomethacin as a Model Drug
The present study was performed to explore the matrix property of Ficus glomerata fruit mucilage for making transdermal patches. The mucilage was evaluated for its physicochemical properties. Various transdermal patches of indomethacin were prepared by solvent evaporation technique using different proportions of F. glomerata fruit mucilage. The compatib...
متن کاملImpact of multicellular tumor spheroids as an in vivo-like tumor model on anticancer drug response
The incidence of colorectal cancer is higher in men than in women, amounting to 15% of cancer-related diseases as a whole. As such, undesirable effects, arising from the administration of current chemotherapeutic agents (the FOLFIRI/FOLFOX combinations), which are exerted on the remaining non-cancerous tissues and/or cells, have contributed to the occurrence of resistance to multiple drugs, thu...
متن کاملpassivity in waiting for godot and endgame: a psychoanalytic reading
this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomeditsinskaya Khimiya
سال: 2010
ISSN: 2310-6905,2310-6972
DOI: 10.18097/pbmc20105606674